One cause for this issue can be change in password for
account with which Application pool is running for changing the Managed account
password follow below blog post:
(Never change it from IIS directly)
If this is not your case then it can be below issue:
If you check the eventvwr logs you will see below entry in
it:
The Module DLL 'C:\Program Files\Common
Files\Microsoft Shared\Web Server Extensions\14\isapi\owssvr.dll' could not be
loaded due to a configuration problem. The current configuration only supports
loading images built for a x86 processor architecture.
Solution:
1.
Open IIS by typing inetmgr in RUN.
2.
Click on Application pools
3.
Click on particular Application pool for your
site
4.
Right Click Advance settings
5.
Set Enable 32-bit applications to false
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